穿心草酮对Iso致大鼠心肌损伤的保护作用

The Protective Effect of Conscora Lucidissima Xanthones on Isoproterenol Induced Myocardial Damage in Rats

给大鼠每天ｓｃ异丙肾上腺素（Ｉｓｏｐｒｅｎａｌｉｎｅ，Ｉｓｏ）０．８３μｍｏｌｋｇ－１造成的心肌损伤的模型上观察３种穿心草口山酮（ｘａｎｔｈｏｎｅ，Ｘａｎ）的作用．结果表明，３种Ｘａｎ均可明显减轻由异丙肾上腺素引起的心肌损伤，抑制谷草转氨酶（ＧＯＴ）和乳酸脱氢酶的漏出，减少异丙肾上腺素引起的心肌丙二醛（ＭＤＡ）的积聚，显著提高心肌中ＳＯＤ活性．提示Ｘａｎ对缺血性心脏病可能有一定的保护作用．

It was observed that cardioprotective action of 3 xanthones (Xan) on the myocardial injury model produced by subcutaneous injection of isoproterenol (0.83 μmol·kg·d-1) into rats. Pretreatment with 2 mg·kg-1 of Xan-Ⅰ,Xan-Ⅱ and Xan-Ⅲ significantly ameliorated isoproterenol-induced myocardial lesion;lowered the level of plasma glutamic-oxaloaceticamino transferase (GPT) and lactate dehydrogenase (LDH) inhibited the increase of lipid peroxidation products(malondialdehde,MDA) and enhanced SOD activity .The potency of xans is Xan-Ⅰ>Xan-Ⅲ>Xan-Ⅱ.