狂犬病患者血清中可溶性白细胞介素-2受体的检测及其意义

DETECTION OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR IN PATIENTS WITH RABIES AND LTS SIGNIFICANCE

采用 ELISA 双抗夹心法对本院1988～1993年14例具有特异性诊断依据的狂犬病患者血清进行可溶性白细胞介素-2受体(Soluble interleukin-2 receptor sIL-2R)检测,同时,与14例正常健康者血清对照,结果显示,狂犬病患者血清 SII-2R 含量为671.20±157.10u/ml,明显高于对照组220.60±8110u/ml(P<0.05)。提示狂犬病患者在发展过程中,不仅有 sIL-2R 参与,而且与该病的发生、发展及死亡密切相关。

Soluble lnterleukin-2 receptor(sll-2R)in serum of 14 specifically diagnosed rabies pa- tients was examined by ELISA with 14 healthy prersons’as control.Serum sIL-2R of patients with rabies was significantly higher than that of the controls(671.2±157.lu/ml Versus 220.6±87.4u/ ml,P<0.05).This result shows that sIL-2R is involved in the pathogenetimechanism of rabies.The interrelation between sIL-2R and patients with rabies was discussed.