异烟肼乙酰化代谢的遗传分型

STUDY OF THE ISONIAZID ACETYLATOR PHENOTYPE SHANGHAI FIRST PNEUMOLOGY HOSPITAL

目的 研究异烟肼乙酰化遗传型。方法 测定口服0.3g异烟肼后2、4、5、8小时血浆和尿中异烟肼及乙酰异烟肼的浓度。结果 测定30人次8小时的血浓分布的直方图,在≤0.3,>0.31≤1.0及>1.0ug/ml范围内明显分成三个组区,分类为快(28％)、中(53％)及慢(20％)乙酰化代谢遗传型。70名病人服异烟肼后8小时,测定尿中排出的乙酰异烟肼对异类肼(酸不稳定的异烟腙类)的比值也明显分为三个组区,慢型(20％)在≤2.1,中间型(55％)>2.1≤10,快型(25％)>10。结论 尿中乙酰异烟肼对异烟肼的比值可以分出异烟肼乙酰化的代谢遗传型。

To study the isoniazid acetylator Phenotype. Methods The concetrations of isoniazid and acetylisoniazid in plasma and urine at 2, 4, 5 and 8 hours after an oral of 0. 3g isoniazid was determined. Results The distribution of 8 hours isoniazid concentrations by the histogram for the 30 subjects is separated clearly into 3 groups at the concentration≤0.3, >0. 3≤1. 0 and >1.0ug/ml and is classified rapid (28%) , intermediate (53% ) and slow (20%) acetylator phenotype respectively. In the 70 patients at 8 hours after administration isoniazid the ratio of urinary excretion of acetylisoniazid to isoniazid (acid - labile hydrazones)is separated too into 3 groups at≤2. 1, >2.1≤10 and>10 and is classified slow(20%) ,intermediate(55% ) and rapid (25%)acetylator phenotype respectively. Conclusion. The ratio of urinary excretion of acetylisoniazid to isoniazid could classity acetylator phenotype.