糖尿病控制程度与糖尿病视网膜病变的关系

Blood glucose control and diabetic retinopathy

采用1：1配比病例对照研究探讨了糖尿病控制程度与糖尿病视网膜病变的关系。以曾经最高血糖值、平均空腹血糖和是否发生过酮症酸中毒反映糖尿病控制程度。通过条件Logistic回归分析方法，分析病例（n=105）、对照（n=105）得出以下结果：单因素分析显示糖尿病控制不佳者患糖尿病视网膜病变的危险性增大；最高血糖值、平均空腹血糖、酮症酸中毒三指标的OR值分别为2.15（95％CI：1.28～3.61）、2.19（95％CI：1.55～3.10）、3.67（95％CI：1.49～9.05）。用潜在的混杂因素调整后，平均空腹血糖的作用仍显著；而最高血糖值和酮症酸中毒分别用病程和尿蛋白调整后其作用消失。

The relationship between blood glucose control and diabetic retinopathy was examined in a matched case-control study in Tianjin. Cases (n=105) and Controls (n =105) were included. With the highest blood glucose, average fasting blood glucose and history of ketonuria reflected blood glucose control. Results were obtained from conditional logistic regression analysis. Univariate analysis suggested that the increased highest blood glucose, average fasting blood glucose and history of ketonuria were risk factors of DR. For the highest blood glucose, OR=2. l5 (95%CI: 1.28～3. 61), for average fasting blood glucose, OR=2. 19 (95%CI: 1.55～3. 10), and for history of ketonuria, 0R= 3. 67 (95 %CI: 1. 49～9.O5). After controlling for other risk variables, average blood glucose was still risk factor of DR; but the highest blood glucose and history of ketonuria were not risk factors of DR.