三(2-苯并咪唑亚甲基)胺的钴(Ⅱ)配合物的合成及结构

Synthesis and structure of the cobalt ( Ⅱ ) complexe donated by tri (2-benzimidazyl methyl) amine

目的:人工模拟合成超氧化物歧化酶(SOD)并测定其结构。超氧化物歧化酶是一种金属酶,它具有防御机体内氧自由基损害的功能。它的活性中心是以咪唑桥联的多核过渡金属配合物。而且它还有一特性,即当只保留一个金属离子时。其活性不变。方法:以市售分析纯Co(NO_3)_2·6H_2O为原料,将其与配体三(2—苯并咪唑亚甲基)胺(NTB)一起溶于甲醇中共热,粗产物重结晶后溶于二甲亚砜中得红色单晶体。对所得产物分别进行元素分析,红外光谱分析和X—射线晶体结构测定。结果:红外光谱分析结果表明配合物中咪唑氮确与金属离子发生配位。X—射线晶体结构表明,此晶体属于正交晶系,其空间群为Fdd2,晶胞参数为a=31.575A,b=31.623A,c=22.356A,最终的偏离因子R=0.076。结论:本文以三(2—苯并咪唑亚甲基)胺为配体,合成了其钴(Ⅱ)的配合物,其结构与人体细胞中SOD结构相似,为人工模拟合成SOD提供了实验基础。

Objectives:AIMS Synthesize Superoxide dismutase (SOD) and determine its crystal structure. SOD is a kind of enzyme, Which can defend organism from injuries of super -oxygen anionic free radical. Its biological active center is the multinuclear transition metal complexes in which the metal ions are bridged byimidazole. Methods: Co (NO3)2 · 6H2O and tri (2 -benzimidazylmethyl) were dissolved in methol and heated, the production was dissolved in DMSO, then the red snglecrystals were obtained. The elemental analyse, IR spectra, crystal structure were determined. Results: The IR spectra shows two sharp peaks for (δN-H and γc-N due to the N - coordinated imidazole. The crystallographic data as follows: orthorhombic, space group is Fdd2. a = 31. 575A, b=31. 623A , c = 22. 356A. The final discrepancy factors is R = 0. 076. Conclusions: In this paper, We report the synthesis, structure, elemental analyse and IR spectra of the mono nuclear complexe of Co (Ⅱ), whose structure is similar to that of in human body's cell.