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白细胞介素6及其受体结构与功能关系研究进展

Review on the structure-function relationship of interlukin-6 and its receptors
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摘要 白细胞介素6(IL-6)的多种生物学功能是通过其特异性受体白细胞介素6受体(IL-6R)和公共受体gp130共同传递的。近年来,对IL-6、IL-6R及gp130的结构与功能进行了大量的研究工作,为进一步揭示它们之间作用的分子机制以及该系统拮抗剂设计提供了思路。 Interlukin-6 exhibit mutiple biological activities by promoting the sequential association of its ligand-spe-cific receptor, IL-6R and common receptor, gp130. Research on the structure-function relationship of IL-6 and its receptors has been reported and it contributed to the ligand-receptor binding mechamism and the antagonists design of IL-6 and its receptors.
作者 宋伦
机构地区 军事医学科学院基础医学研究所
出处 《生物技术通讯》 CAS 1997年第1期29-32,共4页 Letters in Biotechnology
关键词 IL-6 IL-6R GP130 结构与功能 拮抗剂设计 IL-6 IL-6 receptor gp130 structure-function antagonist design
分类号 Q26 [生物学—细胞生物学]
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参考文献19

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生物技术通讯
1997年 第1期

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