慢性HBV感染者血清β_2-微球蛋白的检测及临床意义

SIGNIFICANCE OF SERUM β_2-MICROGLOBULIN LEVELS IN CHRONIC HEPATITIS B VIRAL INFECTION

目的 了解慢性HBV感染者血清β_2-MG的水平及其临床意义。方法 采用放射免疫法(RIA)对142例慢性HBV感染者[其中慢性无症状携带者(ASC)21例,慢性肝炎轻度(CmiH)47例,慢性肝炎中度(CmoH)50例,慢性肝炎重度(CseH)16例,肝炎肝硬变(LC)8例]进行血清β_2-MG的检测,并同时检测30例正常人作为对照。结果 血清β_2-MG水平在CseH、CmoH、LC、CmiH、ASC、和正常对照组依次为4.16±1.02、3.19±0.71、2.69±0.60、2.02±0.55、1.56±0.67、2.05±0.55mg/L。ASC组明显低于正常对照组,而CmiH、CmoH、CseH和LC组均明显高于正常对照组(P值均<0.01)。结论 慢性HBV感染者血清β_2-MG水平与肝脏病变的活动程度有关。

The serum levels of p2-microglobuli,(p2-MG) were determined by radioimmunoassay in 142 patients with chronic HBV infection, including 21 with asymptomatic carriers(ASC), 47 chronic mild hepatitis (CmiH), 50 chronic moderate hepatitis( CmoH), 16 chronic severe hepatitis (CseH)and 8 liver cirrhosis (LC), and 30 healthy subjects as controls.The results showed that the serum (p2-MG levels in CseH, CmoH, LC, CmiH, ASC and healthy subjects were 4.16 r1.02,3.19 + 0.71,2.69 + 0.60,2.02 + 0.55, 1.56 + 0.67, 2.05 z 0.55 mg/L, respectively.The serum fk-MG levels were positively correlated with serum ALT(r = 0.45, P<0.01).It is suggested that the serum p2-MG levels might be related to the degree of liver injury in patients with chronic HBV infections.