中华麦饭石阻止二甲黄诱发大鼠肝炎、肝硬变和肝癌的发生

The Protective Effects of Chinese Meaical Stone on DAB-induced Liver Damage,Cirrhosis and Hepatoma in Rats

用二甲基奶油黄诱发wistag大鼠的中毒性肝炎、肝硬变和肝癌模型,同时给予10％中华麦饭石浸液饮用26周。结果显示,实验组肝炎、肝硬变和肝癌的发生率分别为46.2％(6/13)、38.5(5/13)和41.9％(13/31);对照组均达100.0％(13/13、13/13、31/31,P均<0.001)。在肝炎、肝硬变和肝癌期,实验组IL-2活性均显著高于对照组(P<0.05～0.001);辅助T细胞/抑制T细胞比值均显著高于对照组(P<0.05～0.001);血中Mn、Si、Ba、Fe、Zn、Se和Mo显著高于对照组(P<0.05～0.001);Cu和Cr显著低于对照组(P<0.001)。结果表明中华麦饭石通过增强免疫功能和保持微量元素衡定对二甲基奶油黄诱发的大鼠肝炎、肝硬变和肝癌有显著的防治作用。

To find out the effects of Chinese Medical Stone(CMS) on DAB-induced toxic hepatitis,cirrhosis and hepatoma,we put 153 male wistar rats into experiment.Rats were fed with DAB-contained food and they drank 10% Chinese Medical Stone soak for 26 weeks.The results showed that the incidence of hepatitis was 46.2%(6/13),cirrhosis 38.3%(5/13) and hepatoma 41.9%(13/31) in experimental group, while in controls the incidence of hepatitis,cirrhosis and hepatoma were all 100.0%(13/13,13/13, 31/31 ,P< 0.001 ).IL-2 activity was higher in experimental group than in controls for all 3 stages (P<0.05~ 0.001),and the ratio between T helper lymphocytes and T suppressor lymphocytes was higher in experimental group than in controls for all 3 stages(P<0.05~0.001).Serum levels of Mn,Si,Ba,Fe,Zn ,Se and Mo in experimental group were higher than those in controls(P<0.05~0.001),while that of Cu and Cr were lower in experimental group than in controls (P< 0.001).These results indicated that CMS could inhibit the development of DAB-induced hepatitis, cirrhosis and hepatoma, maybe by enhancing immune function and by modulating the trace element levels.