摘要
Twenty one 1,3 dioxolanes with varieties of substituents at 2,4 positions were synthesized by acid catalyzed acetalization and ketalization reactions of glycerol and its modified derivatives. The assignment and quantitative analyses of thermodynamically equilibrated cis and trans 1,3 dioxolanes were completed by 1H NMR. The stereoselective regularity was found in acetalization and ketalization reactions of glycerol and its modified derivatives. The stereoselective regularity of the condensation reactions was reasonably explained by anomeric effect and 2,4 nonbonded interaction.
Twenty one 1,3 dioxolanes with varieties of substituents at 2,4 positions were synthesized by acid catalyzed acetalization and ketalization reactions of glycerol and its modified derivatives. The assignment and quantitative analyses of thermodynamically equilibrated cis and trans 1,3 dioxolanes were completed by 1H NMR. The stereoselective regularity was found in acetalization and ketalization reactions of glycerol and its modified derivatives. The stereoselective regularity of the condensation reactions was reasonably explained by anomeric effect and 2,4 nonbonded interaction.
