醋氯芬酸的鼠伤寒沙门氏菌诱变性试验

The Salmonella typhimurium reverse mutation test Of aceclofenac

应用鼠伤寒沙门氏菌回复突变试验研究了醋氯芬酸的诱变作用。试验选用TA97,TA98,TA100,TA102菌株。当醋氯芬酸的浓度在1,10,100,1000,4000μg/皿,无论加或不加S_9混合物时其对四株沙门氏菌株的回复突变作用均为阴性。结果表明,醋氯芬酸在体外对原核细胞无诱变作用。

The salmonella typhimurium reverse mutation assay was usde to study aceclofenac induced mutation. The strains of TA97, TA98, TA100, TA102 were usde in this experiment, when aceclofenac levels were at 1,10,100,1000,4000μg per plate, It has no reverse mutation effect on the four strains of salmonella whether the S9 mixture was addde of not. The results of the experiment show that aceclofenac has no mutation effects on the procaryotic cell in vitro.