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EDTA间接滴定法测定帕米膦酸二钠含量 被引量:2

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摘要 本法采用EDTA间接滴定测定含量,并与荧光胺衍生化HPLC法进行了比较,该法简便、实用。其平均含量为99.40%(n=5,RSD=0.22%)
出处 《药学与临床研究》 1997年第3期23-24,共2页 Pharmaceutical and Clinical Research
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  • 1张晓青,蒋晔,徐智儒.唑来膦酸及其有关化合物的反相离子对高效液相色谱分离[J].色谱,2004,22(4):428-430. 被引量:3
  • 2钟永祥,张祥斌.帕米膦酸二钠的临床应用进展[J].中华全科医师杂志,2005,4(1):27-29. 被引量:11
  • 3蒋晔,张晓青,徐智儒.高效液相色谱法测定唑来膦酸及其制剂含量[J].药物分析杂志,2005,25(4):406-408. 被引量:7
  • 4Hartigh JD, Langebroek R, Vermeij P, et al. Ion - exchange liquid chromatographic analysis of bisphosphonate in pharmaceutical preparations. J Pharm Biomed Anal, 1993,11:977
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  • 6Daley - Yates PT,Gifford LA,Hoggarth CR. Assay of 1 - hydroxy -3 - aminopropylidene - 1,1 - bisphosphonate and related bisphosphonates in human urine and plasma by high - performance ion chromatography. J Chromatogr , 1989,490:329
  • 7Flesch G,Tominaga N, Degen P. Improved determination of the bisphosphonate pamidronate disodium in plasma and urine by precolumn derivatization with fluroscamine, high - performance liquid chromatography and fluorescence detection. J Chromatogr, 1991,568:261
  • 8Usui T,Kawakami R, higuchi S. Sensitive determination of a novel bisphosphonate, YM - 529, in plasma, urine and bone by high - performance liquid chromatography with fluorescence detection. J Chromatogr B, 1994,652:67
  • 9Usui T, Watanabe T, Higuchi S. Determination of a new bisphosphonate,YM- 175, in plasma, urine, and bone by high-performance liquid chromatography with electrochemical detection. J Chromatogr,1992,584( 2 ) :213
  • 10Fels JP, Guyonnet J, Berger Y, et al. Determination of (4 - chlorophenyl) thiomethylene bisphosphonic acid ,a new bisphosphonate, in biological fluids by high -performance liquid chromatography and fluorescence detection. J Chromatogr, 1989,489:446

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