登革热患者血清白细胞介素-8和可溶性白细胞介素-2受体的变化及其临床意义

Study on the Change of Interleukin-8,Soluble Interleukin-2 Receptor in Patients with Dengue Fever and Its Clinical Significance

本文采用双单克隆抗体夹心ELISA法检测登革热患者血清白细胞介素-8（IL－8）和可溶液白细胞介素-2受体（sIL－2R）的水平，结果发现登革热患者血清IL-8和sIL－2R水平明显升高血清IL-8和SIL－2R的水平与患者发热时间的长短（超过5天和5天以内）、皮疹的性质（充血性皮疹和出血性皮疹）及肝脏损害密切相关，且随患者尿蛋白含量的增加而升高．表明血清IL-8和sIL－2R对判断登革热患者的病情有一定的临床参考价值．

Assay of serum interleukin - 8(IL - 8) and soluble interleukin - 2 receptor(sIL - 2R)level was performed in 38 patients with dengue fever by dengue fever by double sandwich monoclonal antibody (McAb) enzyme linked immunosorbent assay (ELISA). The results showed that the level of serum IL-8 and sIL-2R in patients with dengue fever was significantly in creased as compared with normal controls. The increase of the level of serum IL-8 and sIL-2R correlated with the duration of fever (over 5 days or within 5 days) and the se verity of skin eruption (congestive of hemorrhagic), as well as the impairment of hepatci function. In addition, the level of serum IL-8 and sIL-2R was increased as the level of the urinary protein increasing. Assaying of sernm IL- 8 and sIL-2R may help to estimate the situation of the illness.