胃-食管返流的临床研究

The Clinical Study On Gastroesophageal Reflux

作者采用国产多功能消化道检测仪对80例具有胃－食管返流（GER）症状患者进行了食管测压研究。患者A组33例，内镜及活检食道粘膜正常；B组47例，内镜及活检均证实有食管炎。正常对照组60例。给予B组患者吗丁啉口服后结果显示：（1）A、B两组患者食管不括约肌压力（LESP）、胃－食管屏障压、食管下括约肌（LES）松弛率明显降低，LES松弛时间明显延长、LES长度短于正常，食管蠕动波压力明显降低（P＜0．05，0．01）；（2）B组LESP、胃－食管屏障压明显低于A组（P＜0．05），这与临床上GER症状发生率B组高于A组相符；（3）吗丁啉使B组LESP、胃－食管屏障降压明显升高，但对食管蠕动无影响。因而，应用吗丁啉对LES功能低下引起的GER有治疗作用。

Esophageal motility was investigatal in 80 patients with symtomatic gastroesophageal reflux (GER) by SGY-3 digestive thect motility measuring instrument made in China. Patients were subdivided into two groups based on endoscopy and biopsy. Group A, normnnal endoscopy and biopsy (n=33). Group B, esophagitis (n=47). The results were compared with 60 healthy subjects. The patients with esophagitis were given oral administration of domoperidone. Measured parameters before and after taking medicine were compared. In conclusion: (1) In all of patients, the lower esophageal sphincter pressure (LESP), the gastroesophageal barrier passure (GEBP), the rate of LES relaxation, the amplitude of esophagtal peristalsis and the length of LES (LESL) were sigamcaulty reduced and the time of LES relaxation extend (P<0.05,0.01). (2) The LESP and the GEBP were lower in group B than in group A (P<0.05). These aecorded with the fact that the symptom of GER were more severe in group B than in group A. (3) After taking domperidone, LESP and GEBP were increased by 0.39± 0.48 and 0.34± 0.49 KPa respectively in B group (P<0.05, 0.01) and there was no effect on the amplitude of esophageal peritalsis.