Ⅱ型糖尿病患者甲襞微循环的观察

Observation on Nail Fold Microcirculation of Patients with Non-Insulin Dependent Diabetes Mellitus

本文观察了140例Ⅱ型糖尿病（NIDDM）患者及55例健康人的甲襞循环变化，结果显示NIDDM患者甲襞微循环在管袢清晰度，变异程度，血流速度，红细胞聚集及袢周状态均较正常人有非常显著差别（P＜0．01）。进一步研究发现，病程在5年以上的与5年内的患者比较，有微血管病变的与无微血管病变的患者比较，在形态，流态，袢周状态均有非常显著差别（P＜0．01）。治疗前后比较，在形态，流态有显著差别。提示：NIDDM患者存在明显的微循环障碍，甲襞微循环的观察有助于了解NIDDM患者的病情，改善微循环可能为预防糖尿病微血管病变提供方向。

Microcirculation of nail fold was examined in 140 cases with Non-Insulin Dependent Diabetes Mellitus(NIDDM) and 55 health people. The result showed that the clarity and ariation of capillary loops, the velocity of blood flow in microcirculation, the red cell aggregation and the condition around capillaries had statistically difference between the patients with NIDDM and normal persons(P<0.01) Furthermore, compared with these of the cases whose durations of NIDDM were shorter than 5 years and whose microvasculars were normal, the shape of loops, the state of blood flow and the condition around microvasculars were changed significantly in the patients who had more than 5 year's course of the disease and pathological chango of microcirculation(P<0.01) After treatment for NIDDM, these parameters were improved apparently. In conclusion, the study indicated that there were obvious microcirculation abnormalities in patienis with NIDDM, and the examination of nail fold microcirculation would help discover these kinds of changes and,what was more, improving the state of microcirculation isbeneficial to preventing the pathology of microvasculars of the patients.