乙胺碘呋酮治疗期间心电图的变化及其临床意义

The electrocardiographic changes and clinical signeficance during amiodarone treatment

本文观察了９１例服已胺碘呋酮４周以上患者的心电图改变（包括心率减慢、Ｐ－Ｒ间期及ＱＴｃ间期延长、Ｔ波切迹或双峰、Ｔ－Ｕ融合、Ｕ波增高、Ｕ＞Ｔ等一系列变化）．并发现上述改变与服药总剂量、血药浓度、疗效及与血甲状腺激素水平无明显相关性。通过动物实验发现上述心电图的某些改变与稳定态时的心肌肉药物浓度有密切关系，认为观察治疗期间患者的心电图变化有助于指导用药。

The electrocardiographic changes including slowed heart rate, delaied P-R and QTc intervals, T wave with notch or double peaks, towering U wave or U＞ T, T-U blended and soforth were observed during treatment with amiodarone for a period of at least 4 weeks. The internelationships between these changs, the accumulated amount of amiodarone, the serum levels of the ding,amiodarone's antiarrhythmic action and the serum levels of thyroid hormones were not revealed, but the amiodarone concentrations in the myotardium of experiment animals correlated with above electrocardiographic changes at steady state, The results suggested that the obtained electrocardingrams were useful in monitoring patients being treated with amiedarone.