抑肽酶在风湿性心脏病联合瓣膜病变心内直视手术中的应用

Using of aprotinin in open-heart surgery of rheumatic mnltiple valvular diseases

本文对抑肽酶在风湿性心脏病．联合瓣膜病变心内直视手术中的应用价值作了临床研究。随机选３０例风湿性心脏病联合瓣膜病变的病例，对照组及用药组各１５例。观察指标包括血小板计算，血小板功能测定，纤维旦白降解产物测定，术后纵隔心包引流量，术后总输血量。研究结果证实了抑肽酶在风湿性心脏病长时间体外循环心内直视手术中，其保护血小板及其功能作用，以及减少术后出血有显著效果。

Abstract:The purpost of the clinical investigation was to study usinig of aprotinin in openinto control goup(n=15)the aprotinin group(n=15), obseving objects included platelet count and funtion, fibrinogen degradation product, the amounts of postoperative chest drainage and blood trans fusion. The results suggest aprotinin povides effective protection for platelet count and function, and can markedly reduce postoperative chest drainsge in open -heart suryery under long time cardiopulmonny bypass.