丁丙诺啡对腹部肿瘤手术后患者自控镇痛的临床研究

Study of patient-controled anesthesia(PCA) with anelgisia buprenorphine after abdominal cancer surgery

①目的 评价丁丙诺啡在腹部肿瘤手术后患者自控镇痛 (PCA)的效果和安全性。②方法 1 2 0例肿瘤手术患者在手术后随机分为丁丙诺啡组 (A组 )和芬太尼组 (B组 ) ,每组均为 60例接受PCA治疗。A组使用丁丙诺啡 ,B组使用芬太尼。采用视觉模拟评分法 (VAS)评估。③结果 两组患者 2 4小时总的疼痛缓解程度 (TPR)和 2 4小时总的疼痛差值 (SPID)均无显著性差异 (P >0 .0 5) ,且无任何严重毒副作用。

Objective To evaluate the analgesic efficacy and safety of PCA with buprenorphine after abdominal cancer surgery. Methods One hundred and twenty patients undergoing abdominal cancer were randomly divided into two groups, i.e. buprenorphine group (group A ) and fentanyl group (group B). Intensify of pain was assessed by using VAS with 0 representing no pain and 10 representing the worst pain. Pain intensity difference before and after PCA and pain relief (PR) (0=not relieved, 4=completely relived). Results The two groups were Matched with age, body weight, duration of operation, the time when postoperative pain started and PCA was commened , and the intensity of postoperative pain. There was no significant difference between pain intensity before and after PCA, and PR has no statistic difference between the two groups(P>0.05).Conclusion The analgesic efficacy of PCA with buprenorphine is comparable to that of PCA with fentanyl.