注射给药改口服后首剂给药时间研讨

Time of First Oral Dose Given after the Alternation of Injection to Oral Method

确立药物静注、恒速静滴、肌注改口服后的首剂口服药物时间,其给予时间应以静注、静滴后的初始浓度、肌注后的达峰浓度降至拟定的最低有效浓度所需的时间“T”为基点,在“T”具体时间量上,提前该药1/8达峰时间给药的观点。即“T-1/8tm”给药方法,且论述了“T-1/8tm”、“T-1/6tm”、“T-1/10tm”三种给药法的可行性。发现了在“T-1/8tm”等给药后,静注及多种不同速率静滴及肌注的药-时曲线的相同性。并界定了“T-1/8tm”给药法的必备条件和适用范围。

The time of first oral dose given after the alternation of ⅳ, drip and im to oral method was established. Time given should be based upon the initail concentration after ⅳ and drip and the time (T)required from the maximum concentration after im decreasing to the lowest effective concenttration. This method was called T—1/8 drug giving method.We also discussed and evaluated the feasibility of three kinds of drug-giving methods T—1/8tm, T—1/6tm and T—1/10tm We found that in the method of T—1/8tm, the time curve of ⅳ, drip and im was identical. We established the conditions required and the scope of application of T—1/8tm method.