抑癌基因LKB1的研究进展

Advance of the research in the tumor suppressor gene LKB1

LKBl是一种丝一苏氨基酸蛋白激酶的变异 ,多见于一种常染色体显性遗传疾病 ,以错构瘤为主的肠道息肉症。同时可伴有其它类型的良性肿瘤 ,叫Peutz-Jeghers综合征。自从 1998年被发现以来 ,许多学者把研究重点放在其鉴定和一种调节细胞生长的因子上。同时分析它调节细胞的功能 .在这篇综述中 ,我们详述一些最近令人振奋的研究成果 :LKBl作为一种肿瘤抑制基因可能是通过改变细胞的凋亡而起作用 ,在体内是通过与其它蛋白相互作用如磷酸化或甲基化而控制细胞。

LKB1 is a serine-threonine protein kinase mutated in-patients with an autosomal dominant inherited cancer syndrome predisposing to multiple beaign and malignant tumours,termed Peutz Jeghers syndrome.Since its discovery in 1998,much research has focused on idetifcation and characterization of its cellular roles and analysing how LKB1 might be regulated.In this review we discuss exciting recent advances that LKB1 functions as a tumour suppressor perhaps by controlling cell polarity.We also outline the current understanding of the molecular mechanisms by which LKB1 is regulated in vivo,through interaction with other proteins as well as by proteinphosphorylation and prenylation.