p53突变蛋白表达与肺鳞癌和腺癌生物学行为的关系

RELATIONSHIP BETWEEN p53 EXPRESSION AND BIOLOGIC BEHAVIOR IN LUNG CANCER

目的探讨ｐ５３基因表达蛋白与肺癌生物学行为的关系。方法应用ｐ５３基因表达蛋白的单克隆抗体，用免疫组织化学的亲和素－生物素－过氧化物酶复合物（ＡＢＣ）法，检测１８例肺鳞癌和２１例肺腺癌石蜡切片中ｐ５３突变蛋白的表达。结果和结论肺鳞癌和腺癌ｐ５３突变蛋白阳性表达率分别为４４．４％和５２．４％，两者无显著差异；ｐ５３突变蛋白阳性表达与肺癌患者的临床病理参数和预后无关。

PURPOSE To identify the relationship between p53 expression and biologic behavior in squamous carcinoma and adenocarcinoma of the lung.METHODS The monoclonal antibody to p53 and ABC immunohistochemical methods were used in this study to detect p53 expression in paraffin-embedded sections of squamous and adenocarcinoma of the lung.RESULTS AND CONCLUSIONS The positive rates of p53 immunostaining in squamous carcinoma and adenocarcinoma of the lung were 44. 4% and 52. 4% respectively. No significant difference was found between squamous carcinoma and adenocarcinoma in p53 expression. p53 expression was not correlated to any of our clinicopathological parameters and prognosis of the patients.