AK－2123对人胃癌细胞SGC7901放射后再增殖的抑制作用

INHIBITION OF RADIATION-INDUCED REPOPULATION OF SGC 7901 CELLS WITH AK-2123

目的探讨用化学药物来控制放射后肿瘤（加速）再增殖。方法选用肿瘤放射治疗的化学修饰剂ＡＫ－２１２３，在不同放射强度作用下对人胃癌细胞ＳＧＣ７９０１细胞生长状况的影响，以ＭＴＴ法来检测细胞数量并计算存活率。结果８Ｇｙ放射引起的细胞再增殖较２Ｇｙ明显增强；０．７８ｍｍｏｌ／Ｌ浓度下ＡＫ－２１２３能明显抑制ＳＧＣ７９０１细胞的再增殖，而当ＡＫ－２１２３浓度增高时，此效应逐渐丧失。结论放射导致的ＳＧＣ７９０１细胞的再增殖与放射作用强度或放射导致的细胞灭活程度有关；可以用化学制剂抑制放射后细胞的再增殖，但如果该制剂具有放射增敏作用，则应注意其综合效应。

To investigate chemical control of radiation-induced repopulation in cancer radiotherapy.METHODS SGC 7901 cells, a human gastric carcinoma line,received different radiation doses, aloneor in combination with a chemical modifier of radiation AK-2123. Cells survival was measured by the MTTmethod.RESULTS 8 Gy of X ray irradiation caused a measurable repopulation of SGC 7901 cells. 0. 78 mmol/L of AK-2123 demonstrated an inhibitory effect on radiation-induced repopulation of SGC 7901 cellswhereas there existed a gradual loss of such effects when the AK-Z123 concentration was increased.CONCLUSIONS Radiation-induced repopulation, which could be inhibited by chemicals,might be radiation dose-dependent,i. e. might depend on the cells surviving the irradiation. Chemical drugs can inhibitthe proliferation of irradiated cells, however,if the drugs have radiosensitizing properties, then attentionshould be paid to possible interaction.