摘要
Dynamic observations for 4 weeks were made on left ventricular function and oxygen freeradicals (OFR) in 43 patients who suffered the first attack of acute myocardial intarction and was hospitalizedin Coronary Care Unit within 36 hours. The results showed that Radix Astragali (RA) could strenthen the leftventricicular function and had an effect of scavenging OFR. After administration of RA, the ratio of pre-ejectionperiod/ left ventricular ejection time (PEP/LVET) was decreased , the superoxide dismutase (SOD) activitiesof erythrocytes were increased, and the lipid peroxidation (LPO) concentration of plasma was reduced.There was a significant difference between the RA group and the control group in the parameters mentionedabove. The study demonstrated that the PEP/LVET ratio was closely correlated with SOD and LPO. It sug-gested that the scavenging effect of RA on OFR was one of its mechanisms of cardiotonic action.
Dynamic observations for 4 weeks were made on left ventricular function and oxygen freeradicals (OFR) in 43 patients who suffered the first attack of acute myocardial intarction and was hospitalizedin Coronary Care Unit within 36 hours. The results showed that Radix Astragali (RA) could strenthen the leftventricicular function and had an effect of scavenging OFR. After administration of RA, the ratio of pre-ejectionperiod/ left ventricular ejection time (PEP/LVET) was decreased , the superoxide dismutase (SOD) activitiesof erythrocytes were increased, and the lipid peroxidation (LPO) concentration of plasma was reduced.There was a significant difference between the RA group and the control group in the parameters mentionedabove. The study demonstrated that the PEP/LVET ratio was closely correlated with SOD and LPO. It sug-gested that the scavenging effect of RA on OFR was one of its mechanisms of cardiotonic action.
