摘要
This study aimed to evaluate the effect of tetramethylpyrazine in treating bacterial meningi-tis . Experimental model of rabbit meningitis was induced by intracisternal inoculation ot 2 x 107 colony-formingunits of Escherichia Coli and tumor necrosis factor-a, thromboxane B2 and 6-keto-prostagladin F1a concentra-tions in cerebrospinal fluid of rabbits in different treatment groups were measured at 24 hrs, 27 hrs and 30 hrsafter infection. Results showed that tetramethylpyrazine could significantly lower the concentrations of tumornecrosis factor-a and thromboxane B2 in cerebrospinal fluid. Administration of both tetramethylpyrazine andampicillin could attenuate the antibiotic-induced rapid release of the 2 intlammatory mediators .
This study aimed to evaluate the effect of tetramethylpyrazine in treating bacterial meningi-tis . Experimental model of rabbit meningitis was induced by intracisternal inoculation ot 2 x 107 colony-formingunits of Escherichia Coli and tumor necrosis factor-a, thromboxane B2 and 6-keto-prostagladin F1a concentra-tions in cerebrospinal fluid of rabbits in different treatment groups were measured at 24 hrs, 27 hrs and 30 hrsafter infection. Results showed that tetramethylpyrazine could significantly lower the concentrations of tumornecrosis factor-a and thromboxane B2 in cerebrospinal fluid. Administration of both tetramethylpyrazine andampicillin could attenuate the antibiotic-induced rapid release of the 2 intlammatory mediators .
