摘要
Fe and Zn levels in perilymph in guinea pigs injected with gentamicin(GM)were examined in this experlment,and those leves were compared with their correspondents in CSF,serum andhairs.Preventive and therapeutic actions of seabuckthorn oil and injective gastrodini to hearing losswe observed.The results showed:①Fe content in perilymph and hair in GM ototxic guinea Pigswas increased,and was decreased after prevention and treating. There was no obvious change in CSFand serum.②Zn content in perilymph was increased in GM ototoxic guinea pigs,and was furtherincreased after prevention.Zn contents in serum and hairs were significantly decreased.The resultssuggest that GM ototoxic reaction is related to increasing Fe contents,and elevation ot Zn content isrelated to the compensative reaction of the body.The cjamges of chemical elements in perilymph aremore important than those in CSF,serum and hairs for pathologic changes in the cochlea,seabuckthorn oil can prevent GM ototoxic reaction.
Fe and Zn levels in perilymph in guinea pigs injected with gentamicin(GM)were examined in this experlment,and those leves were compared with their correspondents in CSF,serum andhairs.Preventive and therapeutic actions of seabuckthorn oil and injective gastrodini to hearing losswe observed.The results showed:①Fe content in perilymph and hair in GM ototxic guinea Pigswas increased,and was decreased after prevention and treating. There was no obvious change in CSFand serum.②Zn content in perilymph was increased in GM ototoxic guinea pigs,and was furtherincreased after prevention.Zn contents in serum and hairs were significantly decreased.The resultssuggest that GM ototoxic reaction is related to increasing Fe contents,and elevation ot Zn content isrelated to the compensative reaction of the body.The cjamges of chemical elements in perilymph aremore important than those in CSF,serum and hairs for pathologic changes in the cochlea,seabuckthorn oil can prevent GM ototoxic reaction.
