摘要
In order to evaluate supplemented vitamin E and selenium in terms of safety,we investigated individual and combined effects of vitamin E and selenium at different concentrations on proliferation of a normal baby hamster kidney fibroblast cell line(BHK-21/C13) and ots polyoma virustransformed counterpart (BHK-21/PyY).The results showed that vitamin E(α-tocopherol);at the concentration of 7 μmol/L,stimulated BHK-21/C13 and BHK-21/PyY growth by 11 % and 16% respectively;selenium(sodium selenite),up to 0.1 μmol/L, had no effect on growth of both cell lines ;co-supplementation of vitamin E and selenium at the same concentrations as above increased BHK21/C13 growth rate by 78%,while BHK-21/PyY cell line remained unaltered. The results suggest that co-supplemcntation of vitamin E and selenium at low concentrations is better than separate sup plementotion of them in safety.
In order to evaluate supplemented vitamin E and selenium in terms of safety,we investigated individual and combined effects of vitamin E and selenium at different concentrations on proliferation of a normal baby hamster kidney fibroblast cell line(BHK-21/C13) and ots polyoma virustransformed counterpart (BHK-21/PyY).The results showed that vitamin E(α-tocopherol);at the concentration of 7 μmol/L,stimulated BHK-21/C13 and BHK-21/PyY growth by 11 % and 16% respectively;selenium(sodium selenite),up to 0.1 μmol/L, had no effect on growth of both cell lines ;co-supplementation of vitamin E and selenium at the same concentrations as above increased BHK21/C13 growth rate by 78%,while BHK-21/PyY cell line remained unaltered. The results suggest that co-supplemcntation of vitamin E and selenium at low concentrations is better than separate sup plementotion of them in safety.
