高尿酸血症和2型糖尿病在代谢综合征中的作用

The effect of hyperuricemia and type 2 diabetes on metabolic syndrome

目的 评价高尿酸血症和 2型糖尿病 (T2DM )在代谢综合征 (MS)中的作用 ,并探讨其可能的作用机制。 方法 对 12 4例高尿酸血症和 5 6例血尿酸正常的T2DM患者的临床资料进行研究。 结果 高尿酸血症合并糖尿病组的体质指数 (BMI)、甘油三酯 (TG)以及冠心病和高血压病的患病率高于血糖正常组 ,且BMI、总胆固醇 (TC)、TG以及冠心病和高血压病的患病率明显高于尿酸正常对照组。 结论 ( 1)高尿酸血症与肥胖、血脂异常明显相关。 ( 2 )高尿酸血症加重了T2DM患者的代谢紊乱 ,T2DM也使高尿酸血症患者的代谢紊乱加重 。

Objective To evaluate the effect of hyperuricemia and type 2 diabetes on metabolic syndrome The possible mechanism will be discussed Methods We analysed all the clinical data of 124 patients with hyperuricemia and 56 type 2 diabetic patients with normal serum uric acid (SUA) concentration Results The prevalences of hyperuricemia in diabetes and impaired glucose regulation (IGR) group were higher than those in normal glucose group (43 5% and 33 9% vs 22 6%) Hyperuricemia was closely associated with obesity and hypertriglyceridemia in our study In group with hyperuricemia and diabetes, the body mass index (BMI), triglyceride (TG) and the prevalences of CHD and hypertension were higher than those in normal glucose group BMI,TG, total cholesterol (TC) and the prevalence of CHD and hypertension were higher in hyperuricemia group than those in the normal SUA group Conclusions (1)Hyperuricemia is associated with obesity and dyslipidemia (hypertriglyceride and hypercholesterol) (2) Hyperuricemia makes the metabolic disorder worse in diabetes patients, and diabetes also makes the metabolic disorder worse in hyperuricemia patients Hyperuricemia and diabetes alone or in combination advance atherosclerosis, CHD and hypertension