老年高血压性肥厚性心肌病动脉顺应性分析

Aortic compliance in elderly patients with hypertensive hypertrophic cardiomyopathy

本文对１９例老年高血压性肥厚性心肌病（ＨＨＣＭＥ）、２１例老年高血压伴左心室肥厚（ＬＶＨＥ）及３０例健康老年人的主动脉顺应性（ＣＡ）进行超声检测。结果发现，两组高血压患者的动脉顺应性均比正常组明显减退（Ｐ＜０，０１），ＨＨＣＭＥ组又显著低于ＬＶＨＥ组（Ｐ＜０．０１）。ＣＡ与左心室壁相对厚度（ＲＷＴ）等呈显著负相关（ｒ＝－０．４６４～－０．７１１，Ｐ＜０．０１），与左房室瓣ＥＦ斜率（ＥＦＶ）等呈显著正相关（ｒ＝０．４４８～０．６１６，Ｐ＜０．０５～０．０１）。上述结果提示，动脉顺应性的严重减退是ＨＨＣＭＥ的又一重要特征。

Echocardiographic measurements of aortic compliance were performed in elderly patients of 19 hypertensive hypertrophic cardiomyopathy(HHCME), 21 hypertension with left ventricular hypertrophy(LVHE) and 30 aged healthy subjects. The results showed that the value of aortic compliance(CA) of two hypertensive groups were hath markedly lower than that of control group(P<0.01), CA of HHCME group decreased much more than that of LVHE (P<0.01).CA of HHCME group was negatively correlated with relativewall thickness,left ventricular mass index, isolated ventricular septum thickness, posterior wall thickness(r=-0.464～0.711, P<0.05～0.01 ), positively with rapid filling velocity, EF velocity(r=0.448, r=0.616, P<0.05～0.01). These findings suggested that the seriously lowered aortic compliance was another important characteristic of HHCME and improving aortic compliance might contribute to regression of myocardial hypertrophy in HHCME.