急性脑血管意外血清高密度脂蛋白及载脂蛋白含量变化与临床观察

Changes of serum high-density lipoprotein cholesterol and apolipoproteins in patients with acute cerebrovascular accident

观察７０例缺血性脑梗塞、５５例脑出血患者和健康人血脂、脂蛋白及ＡｐｏＡ_１、Ｂ含量，结果显示急性脑血管意外病人ＴＣ、ＴＧ、ＬＤＬ－Ｃ虽有升高，但无非常显著差异；而ＨＤＬ－Ｃ及ＡｐｏＡ_１水平下降，ＨＤＬ－Ｃ／ＴＣ、ＨＤＬ－Ｃ／ＬＤＬ－Ｃ比值异常非常显著。认为对高危病人行ＨＤＬ－Ｃ及ＡｐｏＡ_１测定以及使用能提高ＨＤＬ及ＡｐｏＡ１水平的药物改善脂类代谢异常对预防脑血管意外有一定意义。

serum HDL cholesterol and apolipoproteins (A1,B) were determined in 70 cases of ischemic-cerebral infarction, 55 cases of cerebral hemorrhage and normal control group. The results showed that the TC, TG, LDL-C in acute cerebrovascular accidents in serum were higher, but there were no significant. the level of HDL-C and apoA1 in serum was lower than control group(P<0.001), HDL-C/TC and HDL-C/LDL-C were abnormal,(P<0.005, P<0.001). It suggested that estimation of HDL-C, apoA, and administration of drugs imporving lipid metabolism would be valuable to prevent cerebrovascular accidents.