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脑出血、颅内肿瘤及精神分裂症患者血清中抗脑抗体的对照研究

.COMPARATIVE STUDY ON THE AN-IBRAIN ANTIBODY IN THE SERUM OFTHE PATIENTS WITH CEREBRAL HEM-ORRHAGE, INTRACRANIAL TUMORAND SCHIZOPHRENIA
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摘要 本文采用补体结合试验及间接荧光免疫试验的方法,对脑出血,颅内肿瘤及精神分裂症患者血请中进行抗脑抗体的对照研究,其结果为:在补体结合试验中,精神分裂症组的抗脑抗体滴度最高;颅内肿瘤组次之;脑出血组则居第三泣,而正常对照组的抗体滴度最低,若以抗体滴度1:32倍为异常,则异常率分别为:精神分裂症患者87%,颅内肿瘤患者71%,脑出血息者6.6%,而正常人均为阴性。各组之间均有非常显著性差异(P<0.0l).同时采用间接荧光免疫的方法,其结果为lgG阳性,而IgA、lgM均为阴性。研究结果表明抗脑抗体力lgG。 With the complement一fixation testand indirect fluorescent-immune assaymethod, the ABA in the serum of the pa-tients with cerebral hemorrhage,intracranialtumor, schizophrenia and the normal sub-jects were studied respectively, The resuItshowed that in the complement一fixationtest , the ABA titer was the highest inschozophrenia grdup, less highest in the in-tracranial tumor group ,the third highest inthe cerebal hemorrhage group ,and the low-est in the nomal subjects. If we regardedABA titer l :32 as abnormal ,the abnormalrate were as follovVs : the schizophrenic pa-tients were 87%, patients with intracranialtumor were 71%, with cerebral hemorrhagewere 6.6%,the normal subjects were nega-tive. It showed significant statistic differ-ence among the fOur groups.(P< 0.0l ).The fluorescent一immune assay gived thepositive and negative teaction for lgG andIgA, IgM respectively. The paper revealed that ABA really ex-isted either in neurological or psychotic dis-eases. It was the first time proved that theABA waS IgG.Thus the finding of ABA inneuroIogical and psychotic diseases con-firmed the involvent of immune factOrs inthe developn1ent of the diseases and provideafurther clue for a subjective assay methodfor some parameters of those diseases.
出处 《中国民康医学》 1995年第2期89-93,共5页 Medical Journal of Chinese People’s Health
关键词 抗脑抗体 脑出血 颅内肿瘤 精神分裂症 补体结合试验 间接荧光免疫试验 ABA,cerebral hemor-rhage , intracranial tumor, schizophrenia,complement一fixation text , indirect fluores-cent-mmune assay.
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  • 1解学孔,唐盛孟,邬宗秀,吕晓兰,刘忠强,申黎青,程建国.癫痫患者循环免疫复合物的测定[J]青岛医学院学报,1988(01).

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