脑出血、颅内肿瘤及精神分裂症患者血清中抗脑抗体的对照研究

.COMPARATIVE STUDY ON THE AN-IBRAIN ANTIBODY IN THE SERUM OFTHE PATIENTS WITH CEREBRAL HEM-ORRHAGE, INTRACRANIAL TUMORAND SCHIZOPHRENIA

本文采用补体结合试验及间接荧光免疫试验的方法，对脑出血，颅内肿瘤及精神分裂症患者血请中进行抗脑抗体的对照研究，其结果为：在补体结合试验中，精神分裂症组的抗脑抗体滴度最高；颅内肿瘤组次之；脑出血组则居第三泣，而正常对照组的抗体滴度最低，若以抗体滴度１：３２倍为异常，则异常率分别为：精神分裂症患者８７％，颅内肿瘤患者７１％，脑出血息者６．６％，而正常人均为阴性。各组之间均有非常显著性差异（Ｐ＜０．０ｌ）．同时采用间接荧光免疫的方法，其结果为ｌｇＧ阳性，而ＩｇＡ、ｌｇＭ均为阴性。研究结果表明抗脑抗体力ｌｇＧ。

With the complement一fixation testand indirect fluorescent-immune assaymethod, the ABA in the serum of the pa-tients with cerebral hemorrhage,intracranialtumor, schizophrenia and the normal sub-jects were studied respectively, The resuItshowed that in the complement一fixationtest , the ABA titer was the highest inschozophrenia grdup, less highest in the in-tracranial tumor group ,the third highest inthe cerebal hemorrhage group ,and the low-est in the nomal subjects. If we regardedABA titer l :32 as abnormal ,the abnormalrate were as follovVs : the schizophrenic pa-tients were 87%, patients with intracranialtumor were 71%, with cerebral hemorrhagewere 6.6%,the normal subjects were nega-tive. It showed significant statistic differ-ence among the fOur groups.(P< 0.0l ).The fluorescent一immune assay gived thepositive and negative teaction for lgG andIgA, IgM respectively. The paper revealed that ABA really ex-isted either in neurological or psychotic dis-eases. It was the first time proved that theABA waS IgG.Thus the finding of ABA inneuroIogical and psychotic diseases con-firmed the involvent of immune factOrs inthe developn1ent of the diseases and provideafurther clue for a subjective assay methodfor some parameters of those diseases.