高抗素治疗精神分裂症的双盲对照研究

I.Douhle Blind Study of Clopenthix-soltreating Schizophrenia

本文采用随机双盲对照方法，用高抗素与氯丙嗪治疗６４例精神分裂症进行了对照研究。高抗素组３６例，氯丙嗪组２８例，剂量：高抗素４８．２±１８．４ｍｇ／ｄ、氯丙嗪３８０±９８．５ｍｇ／ｄ高抗素显效率５５．６％（２０／３６），有效率８６．２％（３１／３６）；氯丙嗪显效率５７，１％（１６／２８）、有效率８２．１％（２３／２８）．两组显效率与有效率采用Ｒｉｄｉｔ分析均无显著差异；ＢＰＲＳ各因于减分及Ｔｅｓｓ因子分两组间对照亦无显著性差异。

sing random double blind comparisonmethod, we studied 64 schizophrenic pa-tients treated by clopenthixol and chlorpro-mazine(36 patients treated by clopenthixol ,28 patients treated by chlorpromazine). Thedosage were:clopenthexol,48.2+18.4mg/d.chlorpromazine,380+98.5mg/d.The ef-fectual rate of clopenthixol was 55.6% (20/36),the effective rate was 86.2% (3l/36);the effectual rate of chlorpromazine was 57.l% (16/28),the effective rate was 82.l%(23/28),There was no significant differencein the effectual rate and the effective ratebetween the two groups using Ridit Analy-sis. There was also no significant differencebetween the factor losing points in BPRSand TESSI factorial points.