慢性阻塞性肺病患者血管紧张素转换酶的变化及硫甲丙脯酸疗效观察

The Changes of ACE and Effect Ob-servation on Capt-opril Treatment ofCOPD Patients

我们对５２例慢性阻塞性肺病（ＣＯＰＤ）患者和３５例正常人血管紧张素转换酶（ＡＣＥ）进行了测定，并对其中２１例慢性肺心病急性发作期患者进行了硫甲丙脯酸（ＣＰ）治疗试验。结果显示：肺气肿患者与正常对照组ＡＣＥ含量差异不明显（Ｐ＞０．０５），而肺心病患者与正常对照组相比，血清ＡＣＥ降低，差异有显著性（Ｐ＜０．０５），加用硫甲丙脯酸治疗后，ＡＣＥ进一步降低，临床心衰症状改善。表明ＡＣＥ在低氧状态下对肺动脉高压的发病起重要作用，而硫甲丙脯酸不失为治疗该病的较有前途的药物。

erum angiotensin converting enzyme(ACE)levels of 52 patients with chronic ob-structive pulmonary disease (COPD)and 35normal subjects as control were measured.And 21 of these patients who were duringthe acute attack of chronic cor pulmonalewere treated by captopril (CP). There wasno significant difference in serum ACE levels between the patients wigh chrionic bron-chitis pulmonary emphysema and the nor-mal control group (P>0.05).But serum ACE levels of patients with cor pulmonals were remarkably lower than those of the control grouo (P<0.05).After the treat-ment of CP,the serum ACE levels of pa-tients with cor pulmona became much low-er ,but the drug produced improvement on the clinkical symptoms of heart failure The reasuls showed ACE played an important role in the pulmonary hypertension in the hypoxia .The CP had curative effect on pa-tients with COPD.