猕猴高脂造型不同时期脑动脉内皮的扫描电镜观察

SEM OBSERVATION OF ENDOTHELIAL ON THE CEREBRAL ARTERIES OF THE RHESUS MONKEYS IN THE DIFFERENT STAGES OF AT HERO GENIC PROCESS

高脂高胆固醇加用肾上腺素和甲基硫氧嘧啶喂养成年(10—13岁)猴16个月,SEM下可见,大脑中动脉内皮细胞轻度水肿,表面有较多胞质突起和浅表破溃,微绒毛减少。造型28个月,大脑中动脉内皮细胞水肿,质膜泡突起更明显,有些部位融合成块状突起,微绒毛基本消失,局部内皮破裂,表面有血细胞和纤维成份粘附。中央支基本无改变。结果表明,高脂血症长期作用可导致大脑中动脉硬化性改变,中央支有较强的耐受高血脂能力。

Adult monkeys were fed with atherogenic diet for 16 months,which had received introvenous injection of epinepharine from 1-6 months, SEM observation of endothelial surface of the middle cerebral arteries in experimental monkeys: a lightly definite edematous feature, cytoplasm projecting and crater disruption of endothelisl surface. The microvilli was decreased. The animals were fed with at herogenic diet for 28 months, a serious degree definite edematous feature and vacuole could be seen in the middle cerebral arteries, local endothelial mixed together lump條ike projecting, Numerous en dothelial crater and disruption seem to be localized at certain parts. In the majority of such lesions covering of fibrin-like materials and blood cells,the microvilli disappeared. The enothelial surface of central branches of the middle cerebral arteries was lightly damaged. The results shows that hyperlipidemia would result in some changes in the pathogenesis of arteriosclerosis of the middle cerebral arteries. But its central branches resist much to cholesterol induced arteriosclerosis in experimental animals.