日本血吸虫感染动物血清中CAb CAg及CIC水平的动态

DYNAMICS OF CIRCULATING ANTIBODY (CAB),CIRCULATING ANTIGEN(CAG) AND CIRCULATING LMMUNE COMPLEX(CIC) IN SERA FROM RABBITS INFECTED WITH CERCARIAE OF SCHISTOSOMA JAPONICUM

本文对感染10条与50条单、双性血吸虫的4组家兔,在感染后2—18wk,连续检测了血吸虫CAb、CAg及CIC水平,并与正常对照兔进行了对比.结果表明,CAg在感染早期显示高水平,CAb在感染中期呈现明显高峰,而CIC在感染后期也有较高水平.阐明了血吸虫感染宿主血清中CAb、CAg和CIC水平的消长规律,也提示了感染宿主CAb、CAg及CIC水平与感染度和单、双性感染有关.

Consecutive detections on CAb,CAg and CIC levels of sera were carried out from 2 to 18 weeks after rabbits exposed to Schistosoma japonicum infection. Rabbits were divided into four groups and each group was infected with 10 or 50,unisexual or bisexual cercariae respectively. The experimental results revealed that CAg appeared in the early period of infection and CAb reached to a peak in the middle period,whereas CIC still remained at a higher level in the late period of infection. The CAg,CAb and CIC levels in different periods after infection with schistosomiasis were closely related to intensity of infection and whether the infec-tion was unisexual or bisexual. The result of this study had clarified the dynamic changes of CAg,CAb and CIC levels in hosts infected with Schistosoma japonicum,and also provided an experimental evidence for the detection of immune phenomena by using a suitable detection method in different periods of Schistosoma japonicum infection.