STUDIES ON THE STEREO-AND ENANTIOSELECTIVE SYNTHESIS OF 11.12-EPOXYSARCOPHYTOL-A,11,12-EPOXYSARCOPHYTOL-A ACETATE AND 11,12-EPOXYCEMBRENE-C.-SYNTHESIS OF 5,9,13-TRIMETHYL-2-ISOPROPYL-12(S),12(S)-EPOXY-14

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摘要 An efficient Synthesis of 5, 9, 13-trimethy1-2-isopropyl-12(S),13 (S)-epoxy-14-bromo-2 (Z), 4 (E). 8 (E)-tetradecatrienenitrile,a key intermediate in the synthesis of antitumor cembranoids including 11,12-epoxy-sarcophytol-A,11,12-epoxysarcophytol-A acetate and 11,12-epoxycembrene-C,was first describedthrough seven step sequence in-32% overall yield from E,E-farnesol. An efficient Synthesis of 5, 9, 13-trimethy1-2-isopropyl-12(S),13 (S)-epoxy-14-bromo-2 (Z), 4 (E). 8 (E)-tetradecatrienenitrile,a key intermediate in the synthesis of antitumor cembranoids including 11,12-epoxy-sarcophytol-A,11,12-epoxysarcophytol-A acetate and 11,12-epoxycembrene-C,was first describedthrough seven step sequence in-32% overall yield from E,E-farnesol.

作者 Xiang Jun YUE Ting Hao Li Yu Lin Li

机构地区 State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Teaching and Research Section of Chemistry

出处《Chinese Chemical Letters》 SCIE CAS CSCD 1995年第3期189-192,共4页 中国化学快报（英文版）

分类号 O62 [理学—有机化学]

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3Mao Jianmin, Li Weidong, Li Ying and Li Yulin(Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry, Lanzhou University, Langzhou)Liang Xiaotian (Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing).Studies on the Total Synthesis of Sarcophytol-A——Synthesis of 2-Isopropyl-2-(3-Methyl-1-Benzoxyl-5-Phenylsulfonyl-3E-Pentenyl )-1,3-Dithiocyclohexane[J].Chemical Research in Chinese Universities,1991,7(4):247-249.
4李卫东,李裕林,李瀛.大环二萜天然产物(±)-Sarcophytol-A和(±)-Echinodol的全合成[J].自然科学进展（国家重点实验室通讯）,1996,6(4):491-494.
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7Yu-Lin LI Wei-Dong LI Ying LI Laboratory of Applied Organic Chemistry,Institute of Organic Chemistry,Lanzhou University,Lanzhou 730000.STUDIES ON THE SYNTHESIS OF ISOSARCOPHYTOL-A[J].Chinese Chemical Letters,1991,2(1):7-8.
8范军,刘伟生,唐宁,唐瑜,谭民裕,郁开北.Synthesis and Structural Characterization of Erbium Complex with Tripodal Ligand, N, N, N′, N′, N″, N″ Hexaisopropyl-2, 2′, 2″-Nitrilotris (2,1-ethoxy) triacetamide (L)[J].Journal of Rare Earths,2002,20(5):378-381.
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10JianGuoYANG XinYuYU HaiHongWU ZhiLinCHENG YueMingLIU MingYuanHE.The Synthesis of 2,4,6-Triisopropyl-1, 3,5-trioxane Catalyzed by Ionic Liquids[J].Chinese Chemical Letters,2005,16(3):299-302. 被引量：2

Chinese Chemical Letters

1995年第3期

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STUDIES ON THE STEREO-AND ENANTIOSELECTIVE SYNTHESIS OF 11.12-EPOXYSARCOPHYTOL-A,11,12-EPOXYSARCOPHYTOL-A ACETATE AND 11,12-EPOXYCEMBRENE-C.-SYNTHESIS OF 5,9,13-TRIMETHYL-2-ISOPROPYL-12(S),12(S)-EPOXY-14

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