摘要
L-519 is a Phenolic compound.In this study,L-519 was found to inhibit the mutagenicity of benzo(a) pyrene[B(a)P] in Salmonella Typhimurium TA 97 and TA 100 and inhibit the cytochrome P-450 mediated metabolism of B(a) P.It also inhibited the epidermal ODC activity induced by croton oil.L-519 also decreased the lipid peroxidation induced by FeSO4 and Cysteine in rat liver microsome system. Our results demonstrated that L-519 exhibited anti-mutagenicity,anti-initiation as well as anti-promotion activities.
L-519 is a Phenolic compound.In this study,L-519 was found to inhibit the mutagenicity of benzo(a) pyrene[B(a)P] in Salmonella Typhimurium TA 97 and TA 100 and inhibit the cytochrome P-450 mediated metabolism of B(a) P.It also inhibited the epidermal ODC activity induced by croton oil.L-519 also decreased the lipid peroxidation induced by FeSO4 and Cysteine in rat liver microsome system. Our results demonstrated that L-519 exhibited anti-mutagenicity,anti-initiation as well as anti-promotion activities.
