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EffectsofDachengqiDecoction(大承气汤)andRhubarbonCellularElectricalActivityintheSmoothMuscleofGuinea-PigTaeniaColi

Effects of Dachengqi Decoction (大承气汤) andRhubarb on Cellular Electrical Activity in theSmooth Muscle of Guinea-Pig Taenia Coli
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摘要 The effects of Dachengqi decoction (DCQ) and rhubarb (Rb) on the spontaneous cellularelectrical activities of guinea-pig taenia coli have been studied by intracellular microelectrode technique.DCQ and Rb both improve the depolarization of cell membrane , speed up the burst ot slow wave and spikepotentials (when the drug concentration was 1 % ,P>0. 05 , 10 % or 20 % ,P<O. 05) , which were dose de-pendent. At the same concentration the effects of Rb were more significant than those of DCQ. These re-sults suggest DCQ and Rb directly enhance the cellular electrical excitability so as to strengthen the con-traction of the colon , is one of the mechanisms of the purgative actiort of these drugs at the cellular level.The ionic basis of the effects might be that DCQ and Rb reduce the K+ conductance of the cell membranesin a resting state. The effects of Dachengqi decoction (DCQ) and rhubarb (Rb) on the spontaneous cellularelectrical activities of guinea-pig taenia coli have been studied by intracellular microelectrode technique.DCQ and Rb both improve the depolarization of cell membrane , speed up the burst ot slow wave and spikepotentials (when the drug concentration was 1 % ,P>0. 05 , 10 % or 20 % ,P<O. 05) , which were dose de-pendent. At the same concentration the effects of Rb were more significant than those of DCQ. These re-sults suggest DCQ and Rb directly enhance the cellular electrical excitability so as to strengthen the con-traction of the colon , is one of the mechanisms of the purgative actiort of these drugs at the cellular level.The ionic basis of the effects might be that DCQ and Rb reduce the K+ conductance of the cell membranesin a resting state.
出处 《Chinese Journal of Integrative Medicine》 SCIE CAS 1995年第2期56-58,共3页 中国结合医学杂志(英文版)
关键词 Dachengqi decoction RHUBARB smooth muscle MICROELECTRODES intracellular record-ing slow wave potential spike potential Dachengqi decoction , rhubarb , smooth muscle , microelectrodes , intracellular record-ing, slow wave potential , spike potential
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  • 1李乐天,毕庚年,张士善.下法治疗急腹症的初步实验研究[J]中医杂志,1980(06).

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