摘要
A computer-assisted advanced simplex method is presented for the simultaneous optimization of multifactor (stationary phase loading, carrier gas dow rate and column temperature) for separation of ten compounds in gas chromatography. A three factors factorial design was used. The method was based on a special polynomial established from fifteen preliminary runs, using resolution as the selection criterion, with connection to a general simplex method. Excellent agreement is found between the predicted data and the experimental results, and most of experiments required in the general simplex method can be omitted.
A computer-assisted advanced simplex method is presented for the simultaneous optimization of multifactor (stationary phase loading, carrier gas dow rate and column temperature) for separation of ten compounds in gas chromatography. A three factors factorial design was used. The method was based on a special polynomial established from fifteen preliminary runs, using resolution as the selection criterion, with connection to a general simplex method. Excellent agreement is found between the predicted data and the experimental results, and most of experiments required in the general simplex method can be omitted.
基金
supported by the National Natural Science Foundation of China.
