环丙沙星、氧氟沙星、依诺沙星等对小鼠单次腹腔注射产生肝损伤作用程度比较
被引量:1
摘要
在对新氟喹诺酮类抗生素小鼠腹腔注射急性毒性试验中发现:这类药在低于1/2~1/4 LD<sub>50</sub>剂量作用下,能引起肝脏重度畸型、粘连。该作用在单次给药后15~20天出现,易被试验操作者忽视。小鼠外观活动无异常。
出处
《四川生理科学杂志》
1995年第Z1期76-76,共1页
Sichuan Journal of Physiological Sciences
同被引文献27
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1魏东,李振华,张乃生.氟喹诺酮类药物的不良反应[J].动物医学进展,2006,27(7):105-107. 被引量:23
-
2沈建忠.动物毒理学[M].北京:中国农业出版社,2004.83-87.
-
3Owens R J, Ambrose P G.Antimicrobial safety :focus on fluoroquinolones[ J] .Clin Infect Dis ,2005,41 ( Suppl 2) : 144-157.
-
4Barrett M J,Lo~n I S.Gemifloxacin-associ~ed neurotoxicity presenting as encephMopathy[J].Ann Pharmacother,2009,43 (4):782-784.
-
5Grill M F,Maganti R K.Neurotoxic effects associmedwith antibiotic use:managementconsiderations[J].BrJ Clin Pharmacd, 2011,72(3):381-393.
-
6Burkhardt J E, Hill M A,Turek J J, et al.Uhrastructural changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinolone [ J ].Vet Pathol, 1992,29 (3) : 230-238.
-
7Carbone M, Pennisi M G, Masucci M, et al.Activity and postantibiotic effect of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin against feline Bordetella bronchiseptica isolates[ J] .Veterinary Microbiology, 2001,81 (1) :79-84.
-
8Jones R, Reid L.The effect of pH on Alcian Blue staining of epithelial acid glycoproteins. I. Sialomucins and sulphomucins ( singly or in simple combinations) [ J ]. Histochem J, 1973,5 ( 1 ) : 9-18.
-
9Matsuo H, Ryu M,Nagata A, et al.Neurotoxicodynamics of the interaction between ciprofloxacin and foscarnet in mice [ J ]. Antimicrob Agents Chemother, 1998,42(3) :691-694.
-
10Motomura M ,Kataoka Y,Takeo G, et al.Hippocampus and frontal cortex are the potential mediatory sites for convulsions induced by new quinolones and non-steroidal anti-inflammatory drugs[ J ].Int J Clin Pharmacol Ther Toxico1,1991,29(6):223-227.
-
1野运卓,孙晓光.用十味中药说明中药炮制的目的及原理[J].中国现代药物应用,2010,4(17):218-218. 被引量:1
-
2崔丹峰.氟喹诺酮类药物的不良反应[J].职业与健康,2005,21(9):1414-1415. 被引量:1
-
3徐秀娟,孙光.氟喹诺酮类药物的不良反应[J].中国误诊学杂志,2004,4(3):465-465. 被引量:3
-
4姚宏伟,李俊.来氟米特对实验性肝损伤作用的研究[J].中国药理学会通讯,2000,17(3):35-35.
-
5杨威,王茜莎,廖琼峰,毕开顺,王敏伟.乌索酸抗实验性肝损伤作用与大鼠经口给药药动学研究[J].中国医药导刊,2009,11(2):267-269. 被引量:1
-
6彭文兴,汪新亮,李焕德.体内药物相互作用新位点-P-糖蛋白[J].中国临床药理学杂志,2001,17(5):386-390. 被引量:10
-
7万国玲,魏群.利福平的药代动力学对老年肺结核病人治疗作用程度的探讨[J].吉林医学信息,1995(11):13-13.
-
8姜宏伟,叶虹.多烯磷脂酰胆碱预防抗结核药对嗜酒肺结核患者的肝损害[J].医药导报,2012,31(12):1590-1591. 被引量:5
-
9糜志远,刘万忠.新氟喹诺酮类抗生素巴洛沙星研究进展[J].中国新药杂志,2005,14(9):1205-1210. 被引量:21
-
10刘晓琰,孙黎,施安国.新氟喹诺酮类抗生素的不良反应[J].药学服务与研究,2004,4(2):178-180. 被引量:22