小剂量人白细胞α－干扰素雾化吸入用于病毒性肺炎疗效观察

STUDY ON TREATMENT OF VIRAL PNEUMONIA WITH ULTRASOUND-SPRAY INHALATION OF SMALL DOSE α-INTERFERON IN CHILDREN

对经病原学确诊的９０例病毒性肺炎，随机分为３组，采用小剂量人白细胞α－干扰素不同途径给药治疗观察。结果表明，雾化给药组在止咳、平喘、肺部罗音及Ｘ线炎症吸收效果均明显优于注射给药组（Ｐ＜０．０１），其住院时间也明显缩短；注射给药组疗效虽逊色于雾化给药组，但仍明显优于对照组。综上提示，小剂量干扰素无论雾化抑或注射给药用于病毒性肺炎均可发挥明显的抗病毒效果，无需大剂量使用；雾化吸入较肌肉注射给药疗效更为显著，在治疗中未发现α－干扰素有毒副作用。

In this report.We studied go cases etiological diagnosed viral pneumonia patients. According to different way treatment by small dose refined α-interferon, patients were randomized into three groups. The result showed that in the ultrasound-spray inhalation group the time of recovery from cough, wheezing and the time of disappearance of the dry and moist rale and X-ray inflammatory shadow in the lungs were much shorter than those in the control group(P<0.01),the therapy effect in the injecting group were inferior to those in the ultrasound-spray inhalation group, but superior to those in the control one. It came to the conclusion that the therapy effect treating viral pneumonia with smoll dose α-interferon by ultrasound-spray inhalation is remakable, and no side effect was found in the treatment group during administering α-interferon period.