尼莫地平对猫正中神经体感诱发电位的影响

Effect of nimodipine on cat's evoked potential by stimulating median nerve

取１８只猫，随机分成预防、治疗和对照三组。经眶结扎大脑中动脉主干造成脑缺血。预防组在结扎前半小时、治疗组在结扎即刻鼻饲尼莫地平，然后记录结扎即刻、结扎后０．５ｈ、１．５ｈ、３ｈ的正中神经体感诱发电位（ＭＳＥＰ）。结果显示缺血后不同时间幅值，各组均较前下降，但以预防组下降最小。显示尼莫地平有改善猫ＭＳＥＰ的作用。

Eighteen cats were randomly divided into prevention,treatment and control group.Major trunk of middle cerebral artery was exposed and occluded.Prevention group was given nimedipine 0.5 hour before ischemia by nasal tube.Treatment group was given nimodipine immediately while occlusion by nasal tube.MSEP was recorded separately at immediately,0.5 hour,1.5 hours and 3 hours ischemia.Result shows that peak of three groups all decreased.But prevention group decreased least among three groups.It shows nimedipine can improve cat's MSEP in experimental cerebral ischemia.