微量阿斯匹林对肾病患者血小板聚集功能的影响

Platelets aggregation in idiopathic nephrotic syndrome by M-ASA

本文测定了２７例原发性肾病综合征患者ＡＤＰ诱发的血小板聚集率（ＰＡｇＲ），血液流变学以及影响ＰＡｇＲ的有关因素。结果显示均有不同程度的异常，尤其ＰＡｇＲ明显增高。通过应用微量阿斯匹林（Ｍ－ＡＳＡ）治疗，每日３０ｍｇ，共２个月，联用强的松６周至８周。结果表明：ＰＡｇＲ下降有非常显著意义（Ｐ＜０．０１）．血液粘度有不同程度改善（Ｐ＜０．０５．Ｐ＜０．０２）。提示对临床上处于高粘状态，ＰＡｇＲ明显增高患者，Ｍ－ＡＳＡ不失为一有效的治疗方法。

The platelet aggregation rate (PAgR) by ADP,haemorrheology and factors correlated with PAgR in 27 patients with nephrotic syndrome (NS) were determined.The results showed that there were varying degree of abnormality,especially PAgR high level.NS treated with minute-aspirin (M-ASA)30mg tid for two months,together with prednisome for 6￣8 weeks.PAgR decreased(P<0.01). Blood viscosity was improved (P<0.05,P<0.02).This study indicates that M-ASA is valuable to hyperviscosity and overaggregation in NS.