大肠癌组织雌激素受体、雌二醇和睾酮测定的意义

DETERMINATION OF ESTROGEN RECEPTOR, ESTRADIOL AND TESTOSTERONE IN LARGE INTESTINE CARCINOMATOUS TISSUE

检测30例大肠癌和10例良性大肠疾病病灶中雌激素受体(ER),雌二醇(E_2)和睾酮(T)。结果大肠癌ER阳性率36.6％,大肠癌ER阳性率与肿瘤的部位、组织学类型及Duke's分期均无显著关系,良性大肠病灶及正常大肠粘膜中ER均为阴性。大肠癌组织中T含量各T/E_2值显著高于对照组(P<0.05),但E_2含量各组间无统计学意义(P>0.05)。大肠癌组织中E_2和T水平与ER阳性组和阴性组之间无显著差异。提示大肠癌的发生与E_2和T在体内失衡可能有一定关系,大肠癌不是性激素特异性的靶器官肿瘤。

Estrogen of receptor (ER), estradiol(E2) and testoterone (T) in the tissues of 30 cases large intestine carcinoma and 10 cases of benign large intestine diseases were determined. The result showed that the positive rate of ER was 36.6% in the large intestine carcinomatous tissues. Such positive rate was not related to the tumor sites, the pathological types and Ducke's stages of the large intestine carcinomatous tissues. ER was not found in the patients with benign large intestine, diseases and in normal large intestine mucosa. The T content and T / E2 ratio in the patients with large intestine carcinoma were significantly higher than those of the control group (P< 0.05). But, there were no obvious difference in E2 contents among the large intestine carcinoma, benign large intestine disease and nomal large intestine mucosa( P> 0.05). There were not much difference in the E2 and T levels between ER positive and ER negative large intestine carcinomatous tissues. Our results suggest that the imbalance of E2 and T may play a role in the pathogenesis of large intestine carcinoma.Large intestine carcinoma is not the specific target of sex hormones.