Effect of Base Pairing Property in Three Stems of Hammerhead Ribozyme on Its Catalytic Activity

As is well known, the hammerhead ribozyme has a shorter chain length and is easy to design.The ribozyme that we designed against fragment of polyhedron mRNA of Autographa californica Nuclear Polyhedrosis Virus (AcNPV) was proved to be effective by cleavage experiments in vitro.Using this model,