摘要
Substance P (SP) and vasoactive intestinal peptide (VIP) are neuropeptides synthesized in the dorsal root ganglion (DRG). These neuropeptides diffuse toward the central nervous system and peripheral nerve endings. It is now recognized that almost all the SP-containing DRG cells are small-sized (type B), accounting for 20% of total DRG cell population. SP is thought to be neurotransmitters involved in noxious information transmission for primary sensory afferent fibers, while VIP is also involved in sensory modulation. DRG is defined by Sherrington as the 'Laterally Located Brain', and recently is also called The Brain of Spinal Motion Segment and The Mediator of Low Back Pain. Much attention
