子宫内膜异位症卵泡期性激素改变与不育关系的探讨

Various Sexual Hormonal Changes During Follicular Phase in Patients with Endometriosis and Its Relationship with infertility

39例经腹腔镜检查及症灶活检确认的女性不育症患者，含21例子宫内膜异位症为研究组；18例不明原因及慢性盆腔炎为对照组。在月经周期第9－10天作腹腔镜检查及病灶活检，同时测定血及腹腔液的各种性激素浓度。显示研究组卵泡期平均血清PRL浓度明显高于对照组（P＜0．05）。血清FSH平均浓度明显低于对照组（P＜0．05）。腹腔液E2浓度均值及腹腔液E2／血E2比值偏低，与对照组比较均有显著差异（P＜0．05），提示异位症不育患者的卵泡期性激素水平改变可能与不育有因果关系。

39 cases of infertility, diagnosed by laparoscopy and biopsy, were divided into two groups, one of which consisted of 21 study objects identified as cases of infertility caused by endometriosis, and the other 18 control objects of infetrtility with unknown cause and asociated chronic pelvic inflammatory disease. All cases were examined by laparoscopy and biopsy on the 9th - 10th day of the menastrual cycle. The serum and peritoneal fluid PRL、FSH、LH、E2、P. T Levels were at the same time determined by radio - immunoassay. The result showed as follows: the mean of the serum PRL during the follicular phase in the study group was significantly higher than that in the control group(P<0.05). On the other hand, the mean of the serum FSH in the study group was significantly lower than that in the control group(P<0.05), and the same was also true formean of the peritonealfluid E2 and theperitonealfluid E2/serumE2 ratio(P< 0.05).The results reveal that there is correlation between various sexual hormonal changes during the follicular phase of patients of endometriosis and infertility.