蝮蛇抗栓酶治疗肾病综合征伴高粘血症近期疗效观察

Observation on Short-time Effect of Fushe Kangshuan Mei in Treating Blood Hyperviscosity of Nephrotic Syndrome

为探讨降粘疗法在肾病综合征(NS)治疗中的价值。将48例NS伴高粘血患者随机分为蝮蛇抗栓酶(SVATE)组24例(男16例,女8例;年龄28.2±6.5岁)和对照组24例(男15例,女9例;年龄26.7±8.3岁),对照观察治疗4周后的临床疗效和血液流变学变化。结果表明:SVATE组总有效率为61.67％,明显高于对照组(P<0.01),治疗后血液流变学指标全血比粘度,血浆比粘度,纤维蛋白原、血沉均显著下降(P<0.01、<0.001和<0.05),而对照组除血沉外,均无明显降低。因此,作者认为在常规治疗基础上,加用SVATE治疗有助于改善NS患者的血流变学紊乱。显著提高临床疗效。

To go further into the value of reducing blood viscosity in tre-籺iag aepnrotic syndrome, 48 Patients, suffering from, blood kyperv-iscosity of nephrotic syndrome were divided equally into 2 groups at random Group A: 24 cases (Ml6, F6, age 28.2+6.5yr) treated w-ith Fushe Kangsehuanmei ( SVATE ) Plus routing treatment ( included prednisonectytoxan, indomethacine, persantiae and suiting the reme dy to the case) ; Group B: 24 cases (M15,F9. age 26. 7 + 8. 33yr ) treated with routino treatment The clinical effect and hemorheology indexes were contrasted in two groups 4 weeks after the treatment The results showed that the total response rate of group A(91. 67%) was higher than that of group B( 58.33% ) ( P<0.01 ) , Hemorheolo-gy indexesblood specific viscosity plasma specific viscosity, plasma fibrinogen and erythrocyte sedimentation rate ( ESR ) were obviously reduced in group A before and after the treatment OF SVATE(P <0.0. , <0. 001 and <0.05) , but the difference of those in group. B, excecpt ESR, was not statistically significant (P>0.1>0.05 and >0.5) Therefore it is considered that routine treatment plus the treatment of SVATE could help improve hyperviscosity of the patients with nephrotic syadrome and raise clinical effect mark edly.