鼻咽原发癌与其颈淋巴结转移癌细胞核DNA含量的比较

Comparison of Nuclcar DNA Content in primary and Metastatic Nasopharyngcal Carcinomas

应用ＬｅｉｔＺ─ＭＰＶ Ⅲ型显微分光光度计测定１０例鼻咽原发癌及其颈淋巴结转移癌细胞核ＤＮＡ含量，结果发现：①转移癌细胞核ＤＩ、ＵＤＩ及超过５Ｃ细胞的百分数明显低于原发癌；②转移癌细胞核ＤＮＡ含量分布形式较原发癌可以出现左移、右移、不变等三种形式，并对鼻咽癌转移的发展方向及其转移机制进行了探讨。

ytophotometric DNA contents of tumor cells in primary lesions and the corresponding metastaticlymph nodes were compared in 1 0 cases of nasopharyngeal carcinoma in order to determine whether theDNA content remains stable for lymph node metatstases. The DNA distribution patterns were grouped intothree types, according to the proportion of cell popullations, Changes in DNA patterns between primary andmetastatic lesions were noted in 5/1 0 patients, in the remaining 5, the same DNA distribution patterns werefound for both lesions. The mean values of DI. Unit area DNA index and cell petrcentage exceeding 5c inmetastatic lesions (1.42±0. 20,0.43± 0. 04 and3.50±3.10 resipectively) were decreased significantlycompared with the findifigs in primary lesions( 1.70±.44,0.49±0. 08 and 1 5.31±14. 07,respeetively),which were consistent with the histopathology.Such observations may be useful in future designing of treatment protools.