大肠癌细胞DNA倍体分析及其临床意义

FLOW CYTOMETRIC ANALYSIS OF DNA PLOIDY PATTERN IN CARCINOMA OF LARGE INTESTINE AND ITS CLINICAL SINIFICANCE

应用流式细胞术对５２例大肠癌行肝瘤、交界和残端组织ＤＮＡ倍体分析，以深讨倍体与大肠癌组织学类型、癌浸润深度、淋巴结转移以及临床分期的关系。结果：肿瘤组织均为异倍体，残端组织为二倍体，少数病例残端组织学阴性，而ＤＮＡ含量仍为异常值，Ｓ．Ｇ２、Ｍ（细胞周期）增高，细胞增殖活跃。

NA ploidy of the tumor cells,junction and stump tissue's was analyzed in 52 patients with carcinomaof large intestine by flow cytometry and was correlated with the histological type,depth of invasion,lymphnode metastasis and clinical stages.Aneuploidy was obserbed in all of tumor tissues.The most stump tissueswere diploid.In a few cases,the pathological examination of the stump tissues was,negative,but the DNAcontent was abnormal.S.G2/Mincreased and cell proliferated actively。It pointed out that the range of tumor resection was smaller