经导管硬化家兔胆囊

Transcatheter Sclerosis of the Gallbladder in Rabbits

实验用国产ＺＴ胶、无水酒精、四环素溶液作为硬化剂。手术结扎胆囊管后，行胆囊置管造瘘。一周后以上硬化剂经造瘘导管注入胆囊内；４周后，用ＺＴ胶和无水酒精的家兔胆囊完全硬化为８／１０和９／１０，而用四环素溶液则为２／１０。除用无水酒精后ＧＰＴ有一过性升高外，肝功能和肝组织均无明显损害。提示ＺＴ胶和无水酒精可作为有效和安全的胆囊硬化剂，试用于因胆囊造瘘后胆囊管不通的病人，“生物切除”胆囊。

Domestic ZT adhesive, absolute alcohol and tetracycline solution, acting as sclerosing agents, were used in our experiment. Operative ligation of cystic duct and catheterized cholecystostomy were performed. One week later, the sclerosing agents were injected into the gallbladder through catheter in order to destroy the mucosa of the gallbladder. After four weeks, 8/10 of complete sclerosis was achieved in the gallbladder exposed to ZT adhesive and 9/10 in the gallbladder exposed to absolute alcohol. Except for transient elevation of GPT, there were no obvious changes of liver function and liver tissue. The results suggested that ZT adhesive and absolute alcohol be relatively safe and effective sclerosing agents. Both of them can be used in the patients who have been performed cholecystostomy with postoperatively occluded cystic ducts, in order that we can resect the gallbladder biologically.