摘要
本课题组系列报道微爆破碎肝胆管内结石(Miero-explosion of Biliary Calculi,MEBC)实验与临床应用研究工作,将定向微爆破技术应用于人体肝胆管内结石的破碎,减少了剖腹手术取石率,利用微量炸药爆破时产生的冲击波压力破碎胆石,现在已成功地治愈了235例肝胆管内结石病人,我们设计制造定向微爆器(ZS器),一次性破碎胆石成功率93.2％,治疗效果满意。由于人体肝内血管密集、胆管口径小,在狭窄的肝胆管内进行爆破,需保证安全和适用性,为此,设计了电起爆和非电起爆两种起爆方式和微爆器。ZS器其爆破头直径1.5～1.8mm,可适用于各种纤维内窥镜下爆破碎石。根据结石的类型和物理特性、以及两种起爆器的结构和条件参数、碎石效果,我们完成了2850个样品试验。应用我们研制直径1.8mm的微型压力传感器和微弱信号放大器,结合高速摄影技术、激光全息照相技术,观察分析了肝胆管内结石的爆破作用全过程、冲击波压力和爆炸气体产物成份,对爆破药进行了急性和慢性毒性实验。在此基础上,于1989年5月25日成功地进行了世界首例微量炸药定向爆破人体肝脏内胆道结石的临床应用。
The achievement of this research is a successful application of the technique of micro-explosion to the disintegration of biliary calculi (stones in the intra-hepatic bile ducts) of patients without surgery. Up to the present, 235 cases of biliary duct calculi and gallbladder calculi have been treated. The success rate of blasting stones was 100% by use of the directional micro-explosive instrument made by us, the success rate of micro-explosion first time was 93.2% and the result of treatment are satisfactory. It is safe, effective, practical and easy to be operated. The success of research has greatly decreased the rate of getting biliary calculi by surgery opening abdomen operation.
Considering the density of the blood vessels in the human liver, limitation of space in the hepatic ducts, the security and adaptation, we have designed two type of micro-explosive equipment by different ways to initiate explosion by electric initiator and nonelectric initiator.
出处
《中国现代医学杂志》
CAS
CSCD
1994年第2期17-21,81,共6页
China Journal of Modern Medicine
基金
国家自然科学基金
